Evaluation of structure-function relationships in asthma using multi-detector CT (MDCT) and hyperpolarized (HP) He-3 MRI

摘要

Rationale and ObjectivesWhile multiple detector CT (MDCT) and hyperpolarized gas MRI (HP MRI) have demonstrated ability to detect structural and ventilation abnormalities in asthma, few studies have sought to exploit or cross-validate the regional information provided by these techniques. The purpose of this work is to assess regional disease in asthma by evaluating the association of sites of ventilation defect on HP MRI with other regional markers of airway disease, including air trapping on MDCT and inflammatory markers on bronchoscopy.