Carbon Monoxide Saturated Preservation Solution Protects Lung Grafts From Ischemia-Reperfusion Injury

摘要

ObjectivesIn previous work, we have demonstrated that delivery of low concentrations (250 ppm) of carbon monoxide (CO) via inhalation to donor and/or recipients protects transplanted lungs from ischemia-reperfusion injury (IRI) (improved gas exchange, diminished intragraft and systemic inflammation and retention of graft vascular endothelial cell ultrastructure). In this study we examined whether delivery of CO to lung grafts in the preservation solution could protect against lung IRI.