PGC-1alpha SIRT1 and AMPK an energy sensing network that controls energy expenditure

摘要

Purpose of the reviewPGC-1α has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1α activity is not constant, and can be finely tuned in response to different metabolic situations. From this point of view, PGC-1α could be described as a mediator of the transcriptional outputs triggered by metabolic sensors, providing the idea that these sensors, together with PGC-1α, might be weaving a network controlling cellular energy expenditure. In this review we will focus on how pathologies such as type 2 diabetes and the metabolic syndrome might be related to an abnormal and improper function of this network.