Composite Block Polymer-Microfabricated Silicon Nanoporous Membrane

摘要

Block polymers offer an attractive route to densely-packed, monodisperse nanoscale pores. However, their fragility as thin films complicates their use as membranes. By integrating a block polymer film with a thin (100 μm) silicon substrate, we have developed a composite membrane providing both nanoscale size exclusion and fast transport of small molecules. Here we describe the fabrication of this membrane, evaluate its mechanical integrity, and demonstrate its transport properties for model solutes of large and small molecular weight. The ability to block large molecules without hindering smaller ones, coupled with the potential for surface modification of the polymer and the MEMS style of the support make this composite membrane an attractive candidate for interfacing implantable sensing and drug delivery devices with biological hosts.