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Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

机译：肥胖2型糖尿病患者骨骼肌中金属蛋白酶3蛋白水解系统的TNF-α转换酶/组织抑制剂的损伤调节：人类胰岛素抵抗的新机制

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Aims/hypothesisTNF-α levels are increased in obesity and type 2 diabetes. The regulation of TNF-α converting enzyme (TACE) and its inhibitor, tissue inhibitor of metalloproteinase 3 (TIMP3), in human type 2 diabetes is unknown.

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期刊名称 other
作者
A. Monroy; S. Kamath; A. O. Chavez; V. E. Centonze; M. Veerasamy; A. Barrentine; J. J. Wewer; D. K. Coletta; C. Jenkinson; R. M. Jhingan; D. Smokler; S. Reyna; N. Musi; R. Khokka; M. Federici; D. Tripathy; R. A. DeFronzo; F. Folli;
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年(卷),期 -1(52),10
年度 -1
页码 2169–2181
总页数 23
原文格式 PDF
正文语种
中图分类
关键词
Human type 2 diabetes mellitus Insulin resistance TACE TIMP3;

机译：人类2型糖尿病;胰岛素抵抗;TACE;TIMP3;

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专利

1. Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans [J] . A. Monroy, S. Kamath, A. O. Chavez, Diabetologia . 2009,第10期

机译：肥胖2型糖尿病患者骨骼肌中TNF-α转换酶/金属蛋白酶3蛋白水解系统组织抑制剂的调节受损：人类胰岛素抵抗的新机制
2. Associations between insulin resistance and TNF-α in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes [J] . P. Plomgaard, A. R. Nielsen, C. P. Fischer, Diabetologia . 2007,第12期

机译：患有和不患有2型糖尿病的人血浆，骨骼肌和脂肪组织中胰岛素抵抗与TNF-α的关联
3. A Novel TNF-alpha Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-A(y) Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice [J] . Maekawa Mariko, Tadaki Hironobu, Tomimoto Daisuke, Biological & pharmaceutical bulletin . 2019,第11期

机译：一种新的TNF-α转换酶（TACE）选择性抑制剂JTP-96193防止KK-A（Y）2型糖尿病小鼠和1型糖尿病小鼠糖尿病外周神经病变中的胰岛素抗性
4. The Treatment Effects of Dietary Oils on Diet-Induced Obesity, Lipidemia, and Insulin Resistance in Skeletal Muscle Tissue of Obese Prone Rats [D] . Dunthorne, Karin 2011

机译：日粮油对肥胖易发大鼠骨骼肌组织饮食诱发的肥胖，血脂和胰岛素抵抗的治疗作用
5. Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance [O] . Johan W. E. Jocken, Gijs H. Goossens, Hanneke Boon, -1

机译：胰岛素介导的肥胖2型糖尿病男性和糖耐量正常男性的脂肪组织和骨骼肌脂解抑制
6. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans [O] . Monroy, A, Kamath, S, Chavez, A, 2009

机译：肥胖2型糖尿病患者骨骼肌中TNF-α转化酶/金属蛋白酶3蛋白水解系统组织抑制剂的调节受损：人类胰岛素抵抗的新机制

Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

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