Palladium(II)-Catalyzed Cyclization of Unsaturated Hydroperoxides for the Synthesis of 12-Dioxanes

摘要

The cyclization of γ,δ-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products. A variety of substrates were screened, and synthetic manipulations were accomplished to construct compounds with structural similarity to antimalarial targets.