Recovery from hindlimb ischemia is less effective in type 2 than in type 1 diabetic mice: Roles of eNOS and endothelial progenitor cells

摘要

ObjectiveWe sought to directly compare the effects of type 1 and type 2 diabetes on post-ischemic neovascularization and evaluate the mechanisms underlying differences between these groups. We tested the hypothesis that type 2 diabetic mice have a greater reduction in eNOS expression, greater increase in oxidative stress, and reduced arteriogenesis and angiogenesis resulting is less complete blood flow recovery than type 1 diabetic mice after induction of hindlimb ischemia.