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CYP2B6 CYP2A6 and UGT2B7 Genetic Polymorphisms are Predictors of Efavirenz Mid-dose Concentration in HIV-infected Patients

机译：CYP2B6CYP2A6和UGT2B7遗传多态性是艾滋病毒感染患者EFAVIRENZ中剂量浓度的预测因子

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ObjectiveUDP-glucuronosyltransferase (UGT) 2B7 was recently identified as the main enzyme mediating efavirenz N-glucuronidation. In this study we determined whether selected UGT2B7 polymorphisms could be used to enhance the prediction of efavirenz plasma concentrations from CYP2B6 and CYP2A6 genotypes.

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期刊名称 other
作者
Awewura Kwara; Margaret Lartey; Kwamena W.C. Sagoe; Ernest Kenu; Michael H. Court;
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年(卷),期 -1(23),16
年度 -1
页码 2101–2106
总页数 11
原文格式 PDF
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关键词
CYP2B6 CYP2A6 UGT2B7 genetic polymorphisms efavirenz concentration;

机译：CYP2B6;CYP2A6;UGT2B7;遗传多态性;依非韦伦浓度;

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专利

1. CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients. [J] . Kwara A, Lartey M, Sagoe KW AIDS . 2009,第16期

机译：CYP2B6，CYP2A6和UGT2B7遗传多态性是HIV感染患者依非韦伦中剂量浓度的预测因子。
2. CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients. [J] . Kwara A, Lartey M, Sagoe KW, British Journal of Clinical Pharmacology . 2009,第4期

机译：CYP2B6（c.516G-> T）和CYP2A6（* 9B和/或* 17）多态性是感染HIV的患者依非韦伦血浆浓度的独立预测因子。
3. CYP2B6 (c.516GT) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients [J] . Awewura Kwara, Margaret Lartey, Kwamena W. Sagoe, British journal of clinical pharmacology . 2009,第4期

机译：CYP2B6（c.516GT）和CYP2A6（* 9B和/或* 17）多态性是感染HIV的患者依非韦伦血浆浓度的独立预测因子
4. The Two First-Line Recommended Antiretroviral Regimens for Naive HIV-Infected Patients: Efavirenz-Based Versus Lopinavir-Ritonavir-Based Haart [C] . R. Manfredi, L. Calza, F. Chiodo International AIDS Conference . 2004

机译：幼稚艾滋病毒感染患者的两种第一线推荐的抗逆转录病毒方案：efavirenz为基于Lopinavir-Ritonavir的HAART
5. The molecular epidemiology of ovarian cancer: Protein concentrations, epigenetic modification, and polymorphisms. Examples in cancer etiology, prognosis, and treatment. [D] . Beeghly, Alicia Carola. 2005

机译：卵巢癌的分子流行病学：蛋白质浓度，表观遗传修饰和多态性。癌症病因，预后和治疗方面的例子。
6. CYP2B6 (c.516G→T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients [O] . Awewura Kwara, Margaret Lartey, Kwamena W Sagoe, 2009

机译：CYP2B6（c.516G→T）和CYP2A6（* 9B和/或* 17）多态性是感染HIV的患者依非韦伦血浆浓度的独立预测因子
7. CYP2B6 (c.516G→T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients [O] . Kwara, Awewura, Lartey, Margaret, Sagoe, Kwamena W, 2009

机译：CYP2B6（c.516G→T）和CYP2A6（* 9B和/或* 17）多态性是感染HIV的患者依非韦伦血浆浓度的独立预测因子

CYP2B6 CYP2A6 and UGT2B7 Genetic Polymorphisms are Predictors of Efavirenz Mid-dose Concentration in HIV-infected Patients

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