Bioactive Constituents of the Stem Bark of Mitrephora glabra

摘要

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (>1–3), five polyacetylenic acids/esters (>4–8), and one aporphine alkaloid, liriodenine (>9). The structures of the six new compounds (>1–3, 5, 7, and >8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.