RIGHT ANTERIOR INSULA HYPOACTIVITY DURING ANTICIPATION OF HOMEOSTATIC SHIFTS IN MAJOR DEPRESSIVE DISORDER

摘要

ObjectiveAn intact ability to mount preparatory emotional, cognitive and bodily responses to anticipated environmental change is necessary for adaptive responding. Although abnormal insula activity during aversive anticipation has been observed in Major Depressive Disorder (MDD) individuals, the extent to which shifts in homeostatic state during anticipation affect insular activity in MDD subjects has not been reported. The aim of this study was to use functional Magnetic Resonance Imaging (fMRI) to examine how shifts in homeostatic state affect anticipatory insular activity in MDD.