NMDA receptors on striatal neurons are essential for cocaine cue reactivity in mice

摘要

BackgroundEnvironmental cues associated with cocaine evoke craving and seeking. This process, termed cue reactivity, is a critical element of cocaine addiction. While glutamatergic neurotransmission has been implicated in this effect of cocaine, the precise subtype and localization in the brain of the glutamatergic receptor critical for cocaine cue reactivity is not well understood.