The Association between Incident Self-reported Fibromyalgia and Non-psychiatric Factors: 25-years Follow-up of the Adventist Health Study

摘要

The purpose of the study was to investigate the association between incident self-reported fibromyalgia (FM) and prior somatic diseases, lifestyle factors and health behaviors among 3,136 women who participated in two cohort studies 25–26 years apart (the Adventist Health Study 1 and 2). The women completed a comprehensive lifestyle and medical history questionnaire at baseline in 1976. Information on new diagnosis of doctor-told FM was obtained at the 2^nd survey in 2002. A total of 136 women reported a diagnosis of FM during 25 years of follow-up, giving a period incidence of 43/1,000 or 1.72/1000 per year. In multivariable logistic regression analyses, a significant, dose-response association was found with number of allergies with OR of 1.61 (95% CI:0.92–2.83) and 3.99 (95% CI:2.31–6.88), (p[trend]<0.0001, respectively, for 1 and 2 or more allergies versus none. A history of hyperemesis gravidarum was also associated with FM with OR of 1.32 (95% CI:0.75–2.32) and 1.73 (95% CI:0.99–3.03), (p[trend]<0.05), respectively, for some or all pregnancies versus none. A positive association with smoking was also found with OR of 2.37 (95% CI:1.33–4.23) for ever smokers versus never smokers. No significant association was found with number of surgeries, history of peptic ulcer or taking medications to control various symptoms.