Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

摘要

The type 5 G protein β subunit (Gβ5) can form complexes with members of the Regulator of G protein Signaling 7 (RGS7) family, but the relevance to neuronal G protein signaling is unclear. We report that mouse RGS7/Gβ5 complexes bind to G protein–gated potassium channels and facilitate their functional coupling to GABAB receptors in neurons. These findings identify a novel compartmentalization mechanism critical for ensuring high temporal resolution of neuronal G protein signaling.