Four new prenylated flavonoids (>1–4), a new stilbenoid (>5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of >1 and >2 and the known compounds artonin O (>6), artobiloxanthone (>7), and cycloartobiloxanthone (>8), was determined by analysis of their CD and NMR spectroscopic data. Several of the compounds were cytotoxic towards HT-29 human colon cancer cells, with the most potent being compound >2 and the known compounds >6 and >8. Of the substances obtained, compounds >1 and >7 were the most active in the NF-κB p50 and p65 assay, respectively.
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