Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements

摘要

ObjectiveVolume of subcutaneous xenograft tumors is an important metric of disease progression and response to therapy in preclinical drug development. Non-invasive imaging technologies suitable for measuring xenograft volume are increasingly available, yet manual calipers, which are susceptible to inaccuracy and bias, are routinely employed. The goal of this study was to quantify and compare the accuracy, precision, and inter-rater variability of xenograft tumor volume assessment by caliper measurements and ultrasound imaging.