Chemoselective Reductive Cross-Coupling of 15-Diene-3-ols with Alkynes: A Facile Entry to Stereodefined Skipped Trienes

摘要

A convergent synthesis of highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling of substituted 1,5-diene-3-ols with alkynes. The control of site-selectivity in functionalization of the substituted diene is a central feature of this complex fragment union reaction.