A Highly Selective and General Palladium Catalyst for the Oxidative Heck Reaction of Electronically Non-Biased Olefins

摘要

A general, highly selective oxidative Heck reaction is reported. The reaction is high yielding under mild conditions without the need for base or high temperatures, and selectivity is excellent without the requirement for electronically biased olefins, or other specific directing groups. A preliminary mechanistic investigation suggests that the unusually high selectivity may be due to the catalysts sensitivity to C-H bond strength in the selectivity-determining β-hydride elimination step.