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A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

机译：一种预期二甲氧基二醇与转移癌瘤患者组合施用的2-甲氧基雌二醇研究

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PurposeAngiogenesis inhibition has emerged as a potentially promising treatment strategy for neuroendocrine tumors. 2-Methoxyestradiol (2ME2; Panzem®) is a natural derivative of estradiol with demonstrated anti-angiogenic activity in animal models. We performed a prospective, phase II study of 2ME2, administered in combination with bevacizumab, in patients with advanced carcinoid tumors.

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期刊名称 other
作者
Matthew H. Kulke; Jennifer A. Chan; Jeffrey A. Meyerhardt; Andrew X. Zhu; Thomas A. Abrams; Lawrence S. Blaszkowsky; Eileen Regan; Carolyn Sidor; Charles S. Fuchs;
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年(卷),期 -1(68),2
年度 -1
页码 293–300
总页数 13
原文格式 PDF
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关键词
Carcinoid Neuroendocrine Tumors Bevacizumab Sorafenib;

机译：类癌;神经内分泌肿瘤;贝伐单抗;索拉非尼;

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专利

1. A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors. [J] . Kulke MH, Chan JA, Meyerhardt JA, Cancer chemotherapy and pharmacology. . 2011,第2期

机译：对转移性类癌患者联合使用2-甲氧基雌二醇和贝伐单抗进行的前瞻性II期研究。
2. A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors [J] . Matthew H. Kulke, Jennifer A. Chan, Jeffrey A. Meyerhardt, Cancer Chemotherapy and Pharmacology . 2011,第2期

机译：前瞻性II期研究2-甲氧基雌二醇联合贝伐单抗治疗转移性类癌患者
3. Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518 [J] . Yao James C., Guthrie Katherine A., Moran Cesar, Journal of Clinical Oncology . 2017,第15期

机译：III阶段前瞻性随机比较试验奥德雷德雷德尔德加干扰素Alfa-2b与奥德雷德雷德州的糖尿病患者在先进的类癌肿瘤患者中：Swog S0518
4. Immunological responses induced by the combination of phototherapy and immiinotherapy in the treatment of metastatic tumors [C] . Wei R. Chen, Mark F. Naylor, Robert E. Nordquist, Conference on Biophotonics and Immune Responses; 20080121; San Jose,CA(US) . 2008

机译：光化学疗法与亚免疫疗法联合治疗转移性肿瘤的免疫反应
5. A phase I study of vincristine, escalating doses of irinotecan, temozolomide and bevacizumab (VIT-B) in pediatric and adolescent patients with recurrent or refractory solid tumors of non-hematopoietic origin [D] . Venkatramani, Rajkumar. 2010

机译：长春新碱，伊非替康，替莫唑胺和贝伐单抗（VIT-B）逐步剂量在患有非造血源性复发或难治性实体瘤的儿童和青少年患者中的I期研究
6. Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518 [O] . James C. Yao, Katherine A. Guthrie, Cesar Moran, -1

机译：晚期类癌患者中奥曲肽+干扰素Alfa-2b与奥曲肽+贝伐单抗的III期前瞻性随机比较试验：SWOG S0518
7. Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518 [O] . James C. Yao, Katherine A. Guthrie, Cesar Moran, 2017

机译：III阶段前瞻性随机比较试验奥德雷德雷德尔德加干扰素Alfa-2b与奥德雷德雷德州的糖尿病患者在先进的类癌肿瘤患者中：Swog S0518

A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

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