Photodynamic Inactivation of Bacteria Using Polyethylenimine–Chlorin(e6) Conjugates: Effect of Polymer Molecular Weight Substitution Ratio of Chlorin(e6) and pH

摘要

Background and ObjectivesAntimicrobial photodynamic therapy (APDT) is a novel technique to treat local infections. Previously we reported that the attachment of chlorin(e6) to polyethylenimine (PEI) polymers to form PEI-ce6 conjugates is an effective way to improve ce6 PDT activity against bacteria. The aim of this work was to explore how the polymer molecular weight, substitution ratio (SR) of ce6 and pH value affect the PDT efficacy.