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Detection of Early Response to Temozolomide Treatment in Brain Tumors Using Hyperpolarized 13C MR Metabolic Imaging

机译：利用超极化13C MR代谢成像检测脑肿瘤中粒瘤治疗早期反应的检测

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PurposeTo demonstrate the feasibility of using DNP hyperpolarized [1-¹³C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model.

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期刊名称 other
作者
Ilwoo Park; Robert Bok; Tomoko Ozawa; Joanna J. Phillips; C. David James; Daniel B. Vigneron; Sabrina M. Ronen; Sarah J. Nelson;
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年(卷),期 -1(33),6
年度 -1
页码 1284–1290
总页数 15
原文格式 PDF
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关键词
dynamic nuclear polarization hyperpolarized sup13/supC MRSI brain tumor response to temozolomide;

机译：动态核极化;超极化sup 13 / sup C MRSI;脑肿瘤;对替莫唑胺的反应;

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专利

1. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. [J] . Park I, Bok R, Ozawa T, Journal of magnetic resonance imaging: JMRI . 2011,第6期

机译：使用超极化13C MR代谢成像检测对替莫唑胺治疗脑肿瘤的早期反应。
2. Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate [J] . Ralph E. Hurd, Yi-Fen Yen, Dirk Mayer, Magnetic Resonance in Medicine . 2010,第5期

机译：使用超极化[1-13C]丙酮酸和[1-13C]丙酮酸乙酯在麻醉的大鼠脑中进行代谢成像
3. Metabolic imaging in the anesthetized rat brain using hyperpolarized (1-13C) pyruvate and (1-13C) ethyl pyruvate. [J] . Hurd RE, Yen YF, Mayer D, Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine . 2010,第5期

机译：使用超极化（1-13C）丙酮酸和（1-13C）丙酮酸乙酯对麻醉的大鼠大脑进行代谢成像。
4. Evaluation of high intensity focused ultrasound ablation of prostate tumor with hyperpolarized 13C imaging biomarkers [C] . Jessie E. Lee, Chris J. Diederich, Vasant A. Salgaonkar, Conference on energy-based treatment of tissue and assessment VIII . 2015

机译：高强度聚焦超声烧蚀前列腺瘤与超极性13C成像生物标志物的评价
5. Monitoring tumor response of prostate cancer to radiation therapy by multi-parametric 1H and hyperpolarized 13C magnetic resonance imaging. [D] . Zhang, Vickie Yi. 2014

机译：通过多参数1H和超极化13C磁共振成像监测前列腺癌对放射治疗的肿瘤反应。
6. Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients [O] . Vesselin Z. Miloushev, Kristin L. Granlund, Rostislav Boltyanskiy, -1

机译：超极化的13C丙酮酸对人脑的代谢成像显示脑肿瘤患者中13C乳酸的产生。
7. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging [O] . Ilwoo Park, Robert Bok, Tomoko Ozawa, 2011

机译：利用超极化13C MR代谢成像检测脑肿瘤中粒瘤治疗早期反应的检测

Detection of Early Response to Temozolomide Treatment in Brain Tumors Using Hyperpolarized 13C MR Metabolic Imaging

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