Ultrafast and whole-body cooling with total liquid ventilation induces favorable neurological and cardiac outcomes after cardiac arrest in rabbits

摘要

BackgroundIn animal models of cardiac arrest, the benefit afforded by hypothermia is closely linked to the rapidity in body temperature decrease after resuscitation. Since total liquid ventilation (TLV) with temperature controlled perfluorocarbons induces a very rapid and generalized cooling, we aimed to determine whether this could limit the post-cardiac arrest syndrome in a rabbit model. We especially focused on neurological, cardiac, pulmonary, liver and kidney dysfunctions.