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FRET-based sensor Camui provides new insight into mechanisms of CaMKII activation in intact cardiomyocytes

机译：基于FRET的传感器CAMUI为完整的心肌细胞中的CAMKII激活机制提供了新的洞察力

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RationaleCalcium/calmodulin dependent protein kinase II (CaMKII) is a key mediator of intracellular signaling in the heart. However, the tools currently available for assessing dynamic changes in CaMKII localization and activation in living myocytes are limited.

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期刊名称 other
作者
Jeffrey R. Erickson; Ruchi Patel; Amanda Ferguson; Julie Bossuyt; Donald M. Bers;
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年(卷),期 -1(109),7
年度 -1
页码 729–738
总页数 22
原文格式 PDF
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CaMKII biosensor FRET;

机译：CaMKII;生物传感器;FRET;

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专利

1. Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. [J] . Erickson JR, Patel R, Ferguson A, Circulation research: a journal of the American Heart Association . 2011,第7期

机译：基于荧光共振能量转移的传感器Camui提供了对完整心肌细胞中钙/钙调蛋白依赖性蛋白激酶II激活机制的新见解。
2. Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation [J] . Peter Rellos, Ashley C. W. Pike, Frank H. Niesen, PLoS Biology . 2010,第7期

机译：CaMKIIδ/钙调蛋白复合物的结构揭示了CaMKII激酶激活的分子机制。
3. Alamandine enhances cardiomyocyte contractility in hypertensive rats through a nitric oxide-dependent activation of CaMKII [J] . Itamar Couto Guedes Jesus, Thassio Ricardo Ribeiro Mesquita, Andre Luis Lima Monteiro, American Journal of Physiology . 2020,第4aPta1期

机译：Alamandine通过Camkii的一氧化氮依赖性激活来增强高血压大鼠的心肌细胞收缩性
4. Na:Ca Stoichiometry and Cytosolic Ca-Dependent Activation of NCX in Intact Cardiomyocytes [C] . DONALD M. BERS, ENNETH S. GINSBURG, New York Academy of Sciences International Conference on Na/Ca Exchange . 2007

机译：Na：Ca化学计量和Cytosolic Ca依赖性NCX在完整的心肌细胞中的NCX
5. The subproteome of mitoBKCa channels from cardiomyocytes reveals novel insights into its mitochondrial import mechanism and function. [D] . Zhang, Jin. 2016

机译：来自心肌细胞的mitoBKCa通道的亚蛋白质组揭示了对其线粒体导入机制和功能的新颖见解。
6. PNAS Plus: Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346 [O] . Igor Dikiy, Uthama R. Edupuganti, Rinat R. Abzalimov, 2019

机译：PNAS Plus：单体蓝光传感器EL346对组氨酸激酶激活机制的见解
7. Fluorescence Resonance Energy Transfer–Based Sensor Camui Provides New Insight Into Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Intact Cardiomyocytes [O] . Jeffrey R. Erickson, Ruchi Patel, Amanda Ferguson, 2011

机译：基于荧光共振能量转移的传感器CAMUI在完整的心肌细胞中，进入钙/钙调蛋白依赖性蛋白激酶II活化机制的新洞察力

FRET-based sensor Camui provides new insight into mechanisms of CaMKII activation in intact cardiomyocytes

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