An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors

摘要

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (>7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (>3a-h) with suitably substituted 2-(1H-indol-3-yl)-2-oxoacetaldehyde (>6a-d) under microwave condition. The thioxothiazolidine-4-ones were prepared from corresponding aromatic amines (>1a-e) and di-(carboxymethyl)-trithiocarbonyl (>2). The aldehydes (>6a-h) were synthesized from the corresponding acidchlorides (>5a-d) using HSnBu3.