The purpose of this study was to evaluate the effect of gadoxetic acid(Gd-EOB-DTPA) on measurements of liver stiffness by using magnetic resonance elastography (MRE). In this study, 104 consecutive patients (mean age, 67.7 ± 9.4 years) underwent MRE using a 1.5-T MR scanner equipped with a cylindrical passive driver that was placed across the right chest wall for delivering vibrations. Axial gradient-echo images, which were automatically converted to elastograms that represented stiffness (kPa), were acquired using a continuous sinusoidal vibration of 60 Hz. Two raters independently placed a region of interest on the right lobe of the liver on the elastograms obtained before and after Gd-EOB-DTPA was administered. Liver stiffness was measured using these 2 elastograms and compared using a paired ttest and correlation analysis. No significant difference was observed in liver stiffness before and after Gd-EOB-DTPA was administered (rater 1, P= 0.1200; rater 2, P= 0.3585). The correlation coefficients were 0.986 (rater 1) and 0.984 (rater 2), indicating excellent correlation between the stiffness values before and after Gd-EOB-DTPA was administered. Liver stiffness measured by MRE did not differ before and after Gd-EOB-DTPA was administered.
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