Ablation of p21-Activated Kinase-1 in Mice Promotes Isoproterenol-Induced Cardiac Hypertrophy in Association with Activation of Erk1/2 and Inhibition of Protein Phosphatase 2A

摘要

RationaleEarlier investigations in our lab indicated an anti-adrenergic effect induced by activation of p21-activated kinase (Pak-1) and protein phosphatase 2A (PP2A).