Ethnic differences in glucose disposal hepatic insulin sensitivity and endogenous glucose production among African American and European American women

摘要

ObjectiveIntravenous glucose tolerance tests (IVGTT) have demonstrated lower whole-body insulin sensitivity (SI) among African Americans (AA) compared to European Americans (EA). Whole-body SI represents both insulin-stimulated glucose disposal, primarily by skeletal muscle, and insulin's suppression of endogenous glucose production (EGP) by liver. A mathematical model was recently introduced that allows for distinction between disposal and hepatic insulin sensitivity. The purpose of this study was to examine specific indexes of insulin sensitivity among AA and EA women to determine whether lower whole-body insulin sensitivity in AA may be attributed to insulin action at muscle, liver, or both.