Intravesical Chondroitin Sulfate Inhibits Recruitment of Inflammatory Cells in an Acute Acid-Damage Leaky Bladder Model of Cystitis

摘要

OBJECTIVESReplacement of the glycosaminoglycan (GAG) layer with intravesically-administered GAGs is an effective therapy for interstitial cystitis in at least some patients. Intravesically-administered chondroitin sulfate was previously shown to bind to and restore the impermeability of surface-damaged (“leaky”) urothelium to small ions. This study investigated whether a physiologic effect of “GAG replenishment therapy” altered recruitment of inflammatory cells in an acute bladder damage model.