Amyrisins A - C O-Prenylated Flavonoids from Amyris madrensis

摘要

Three new O-prenylated flavonoids, amyrisins A – C (>1 –>2), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound, polygamain (>4). The structures of >1 – >3 were elucidated based on the analysis of spectroscopic data. Amyrisins B (>2) and C (>3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC50 values of 17.5 and 23 μM, respectively while amyrisin A (>1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (>4) exhibited potent antiproliferative and microtubule depolymerizing activities.