Correlations between the percentage of tumor cells showing an ALK gene rearrangement ALK signal copy number and response to crizotinib therapy in ALK FISH positive non-small cell lung cancer

摘要

BackgroundFISH, using break-apart red (3’) and green (5’) ALK probes, consistently shows rearrangements in < 100% of tumor cells in ALK+ NSCLC. Increased copy numbers of fused and rearranged signals also occur. Here we explore correlations between the percentage of ALK positive cells and signal copy number and their association with response to ALK inhibition.