The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here we present a brief overview of the transcriptional control of this process, with emphasis on two issues. The study of Cd4 expression, that had previously generated important paradigms for transcriptional regulation in eukaryotic cells, now brings new twists to the concept of ‘epigenetic memory’. On the other hand, connections are emerging between transcriptional regulators critical for commitment to either lineage. The present review attempts to integrate these findings and discusses the still elusive mechanisms that match CD4-CD8 lineage differentiation to MHC specificity.
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机译：The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial for the generation of an antigen-responsive and functionally fit T cell repertoire.在这里，我们简要概述了这个过程的转录控制，重点是两个问题。研究了CD4表达的研究，其先前产生了真核细胞中转录调节的重要范式，现在为“表观记忆记忆”的概念带来了新的曲折。另一方面，在转录监管机构之间出现了对任何血统的承诺关键的转录调节器之间的出现。本综述尝试集成这些发现并讨论将CD4-CD8谱系分化与MHC特异性匹配的仍然难以实现的机制。
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