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Genetic and Clinical Determinants of Early Acute Calcineurin Inhibitor-Related Nephrotoxicity: Results from a Kidney Transplant Consortium

机译：早期癌症和临床决定簇急性钙素抑制剂相关的肾毒性：肾移植联盟的结果

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BackgroundCalcineurin inhibitor (CNI)-related acute nephrotoxicity is a common complication of transplantation. Clinical factors and elevated CNI levels are associated with nephrotoxicity; however, they do not completely explain the risk. Genetics factors may also predispose individuals to nephrotoxicity.

机译：BackgroundCalcineurin抑制剂（CNI） - 相关的急性肾毒性是移植的常见并发症。临床因素和升高的CNI水平与肾毒性有关;但是，它们并没有完全解释风险。遗传因素也可能易于促使个体肾毒性。

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期刊名称 other
作者
Pamala A. Jacobson; David Schladt; Ajay Israni; William S. Oetting; Yi Cheng Lin; Robert Leduc; Weihau Guan; Vishal Lamba; Arthur J. Matas;
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作者单位

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年(卷),期 -1(93),6
年度 -1
页码 624–631
总页数 19
原文格式 PDF
正文语种
中图分类
关键词
tacrolimus cyclosporine pharmacogenetics nephrotoxicity calcineurin inhibitor;

机译：他克莫司;环孢霉素;药物遗传学;肾毒性;钙调神经磷酸酶抑制剂;

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专利

1. Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: Results from a kidney transplant consortium [J] . JacobsonP.A., SchladtD., IsraniA., Transplantation: Official Journal of the Transplantation Society . 2012,第6期

机译：早期与急性钙调磷酸酶抑制剂相关的肾毒性的遗传和临床决定因素：肾脏移植联合会的结果
2. Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: A possible interaction between donor and recipient genetic polymorphisms [J] . QuagliaM., TerrazzinoS., BoldoriniR., Journal of Clinical Pharmacy and Therapeutics . 2013,第4期

机译：尽管他克莫司水平低，肾移植患者仍存在严重的急性肾毒性：供体和受体基因多态性之间可能存在相互作用
3. Clinical implementation of pharmacogenetics in kidney transplantation: Calcineurin inhibitors in the starting blocks [J] . ElensL., BouamarR., ShukerN., British Journal of Clinical Pharmacology . 2014,第4期

机译：药物遗传学在肾脏移植中的临床实施：钙调神经磷酸酶抑制剂起步
4. Multiwave technology introducing shear wave elastography of the kidney: Pre-clinical study on a kidney fibrosis model and clinical feasibility study on 49 human renal transplants [C] . Gennisson Jean-Luc, Grenier Nicolas, Hubrecht Regis, 2010 IEEE International Ultrasonics Symposium . 2010

机译：引入肾脏剪切波弹性成像的多波技术：肾脏纤维化模型的临床前研究和49例人肾移植的临床可行性研究
5. The incidence and consequences of acute kidney injury in kidney transplant recipients. [D] . Mehrotra, Anita. 2010

机译：肾移植受者急性肾损伤的发生率和后果。
6. Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients [O] . S. R. Katari, M. Magnone, R. Shapiro, -1

机译：肾移植受者急性可逆他克莫司（FK 506）肾毒性的临床特征
7. Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients [O] . Katari SR, Magnone M, Shapiro R, 1997

机译：肾移植受者急性可逆他克莫司（FK 506）肾毒性的临床特征

Genetic and Clinical Determinants of Early Acute Calcineurin Inhibitor-Related Nephrotoxicity: Results from a Kidney Transplant Consortium

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