Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates

摘要

BACKGROUNDLipids and other biologically active substances accumulate in platelet concentrates (PCs) during storage. Some of these substances have been suggested to modulate immune responses and to play a pathogenic role in the development of transfusion-related acute lung injury. This study compared the content and impact of some biological response modifiers in PCs treated with pathogen reduction (PR) technology and nontreated PCs.