Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De novo insertions cause genetic diseases and cancers, though reliably detecting these occurrences has been difficult. New technologies aimed at uncovering polymorphic insertions reveal that mobile DNAs provide a substantial and dynamic source of structural variation. Key questions going forward include the how and how much new transposition events affect human health and disease.
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机译：移动DNA在塑造我们的基因组方面具有核心作用。我们的一半以上的DNA由散布的重复由Recrotransposons的复制复制和粘贴事件组成。虽然大多数是固定的，但无法模板新副本，但重传扫描静电的重要例外情况。 De Novo插入导致遗传疾病和癌症，但可靠地检测这些事件困难。旨在揭示多态插入的新技术揭示了移动DNA提供了大量和动态的结构变化来源。前进的关键问题包括如何以及多少新的转置事件影响人类健康和疾病。
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