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Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model

机译：肠道碱性磷酸酶给药在新生儿中降低新生儿坏死性小肠结肠炎大鼠模型中的全身炎症细胞因子表达

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BackgroundSupplementation of intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, decreases the severity of necrotizing enterocolitis (NEC)–associated intestinal injury and permeability. We hypothesized that IAP administration is protective in a dose-dependent manner of the inflammatory response in a neonatal rat model.

机译：肠碱性磷酸酶（IAP）的背景，在肠道中表达的内源性蛋白质，降低了坏死性小肠结肠炎（NEC）的严重程度 - 分配肠损伤和渗透性。我们假设IAP施用以新生大鼠模型中的炎症反应的剂量依赖性方式保护。

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期刊名称 other
作者
Rebecca M. Rentea; Jennifer L. Liedel; Katherine Fredrich; Scott R. Welak; Kirkwood A. Pritchard Jr; Keith T. Oldham; Pippa M. Simpson; David M. Gourlay;
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作者单位

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年(卷),期 -1(177),2
年度 -1
页码 228–234
总页数 13
原文格式 PDF
正文语种
中图分类
关键词
Necrotizing enterocolitis Intestinal alkaline phosphatase Systemic inflammation Cytokine;

机译：坏死性小肠结肠炎;肠道碱性磷酸酶;全身性炎症;细胞因子;

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1. Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model [J] . RenteaR.M., LiedelJ.L., FredrichK., Journal of Surgical Research: Clinical and Laboratory Investigation . 2012,第2期

机译：在新生儿坏死性小肠结肠炎大鼠模型中，新生儿使用肠道碱性磷酸酶可降低全身炎症性细胞因子的表达
2. Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model [J] . RenteaR.M., LiedelJ.L., FredrichK., Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 2013,第1期

机译：新生儿肠内碱性磷酸酶的施用降低了新生坏死性小肠结肠炎大鼠模型中iNOS的表达
3. Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model [J] . RenteaR.M., LiedelJ.L., WelakS.R., Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 2012,第6期

机译：在新生儿坏死性小肠结肠炎大鼠模型中，新生儿使用肠道碱性磷酸酶可保护肠道屏障功能
4. The Application of combination of External Drainage from Intestinal Cavity and Peritoneal Drainage on the Surgical Treatment for Neonates with Necrotizing Enterocolitis [C] . Ji-xue Zhao, Xin Fu International Conference on Machinery, Materials and Computer . 2018

机译：肠腔外排水与腹膜腹膜腹膜腹膜外阴菌与坏死性肠菌癌外科治疗的应用
5. Inflammatory Bowel Disease-associated Cytokines Control Wnt Expression in the Intestinal Stem Cell Niche: Implications for Mucosal Healing [D] . Lam, Adria P. 2021

机译：炎症性肠病相关的细胞因子控制肠道干细胞的WNT表达：对粘膜愈合的影响
6. Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model [O] . Rebecca M. Rentea, Jennifer L. Liedel, Katherine Fredrich, -1

机译：新生儿中肠内肠道碱性磷酸酶给药降低了新生儿坏死性小肠结肠炎大鼠模型中的INOS表达
7. Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model [O] . Rebecca M. Rentea, Jennifer L. Liedel, Katherine Fredrich, 2013

机译：新生儿中肠内肠道碱性磷酸酶给药降低了新生儿坏死性小肠结肠炎大鼠模型中的INOS表达

Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model

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