PLATELET ACTIVATING FACTOR AND DISTINCT CHEMOKINES ARE ELEVATED IN MUCOSAL BIOPSIES OF EROSIVE COMPARED TO NON-EROSIVE REFLUX DISEASE PATIENTS AND CONTROLS

摘要

BackgroundA distinction between symptomatic non-erosive reflux disease (NERD) and erosive esophagitis (EE) patientsis supported by the presence of inflammatory response in the mucosa of EE patients, leading to a damage of mucosal integrity. To explore the underlying mechanism of this difference we assessed inflammatory mediators in mucosal biopsies from EE and NERD patients and compared them to controls.