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A fully Bayesian application of the Copas selection model for publication bias extended to network meta-analysis

机译:完全贝叶斯应用于公布偏置的COPAS选择模型扩展到网络元分析

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摘要

The Copas parametric model is aimed at exploring the potential impact of publication bias via sensitivity analysis, by making assumptions regarding the probability of publication of individual studies related to the standard error of their effect sizes. Reviewers often have prior assumptions about the extent of selection in the set of studies included in a meta-analysis. However, a Bayesian implementation of the Copas model has not been studied yet. We aim to present a Bayesian selection model for publication bias and to extend it to the case of network meta-analysis where each treatment is compared either to placebo or to a reference treatment creating a star-shaped network. We take advantage of the greater flexibility offered in the Bayesian context to incorporate in the model prior information on the extent and strength of selection. To derive prior distributions, we use both external data and an elicitation process of expert opinion.
机译:Copas参数模型旨在通过敏感性分析来探索发表偏倚的潜在影响,方法是对与其效应大小的标准误差有关的个别研究发表的可能性进行假设。审查者通常对荟萃分析所包括的一组研究中的选择范围有事先的假设。但是,尚未研究Copas模型的贝叶斯实现。我们的目的是提出一种用于发表偏倚的贝叶斯选择模型,并将其扩展到网络荟萃分析的情况下,在这种情况下,每种治疗均与安慰剂或建立星形网络的参考治疗进行比较。我们利用贝叶斯上下文中提供的更大的灵活性,将关于选择范围和强度的先验信息纳入模型。为了得出先验分布,我们同时使用外部数据和专家意见的启发过程。

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