Increased phospholipase A2 and lyso-phosphatidylcholine levels are associated with surfactant dysfunction in lung contusion injury in mice

摘要

ObjectiveSurfactant dysfunction is an important pathological disturbance in various forms of acute inflammatory lung injury. Previously we reported the presence of significant alterations in the composition and activity of pulmonary surfactant in blunt trauma-induced bilateral lung contusion (LC) injury in rats. This is extended here to a mouse model of unilateral LC, with a focus on compositional and functional surfactant changes associated with permeability injury and increases in activity of secretory phospholipase A2.