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Effect of Acupuncture in Mild Cognitive Impairment and Alzheimer Disease: A Functional MRI Study

机译:轻度认知功能障碍和阿尔茨海默病针灸的作用:一个功能磁共振成像研究

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摘要

We aim to clarify the mechanisms of acupuncture in treating mild cognitive impairment (MCI) and Alzheimer disease (AD) by using functional magnetic resonance imaging (fMRI). Thirty-six right-handed subjects (8 MCI patients, 14 AD patients, and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all the subjects. MRI data acquisition was performed on a SIEMENS verio 3-Tesla scanner. The fMRI study used a single block experimental design. We first acquired the baseline resting state data in the initial 3 minutes; we then acquired the fMRI data during the procession of acupuncture stimulation on the acupoints of Tai chong and Hegu for the following 3 minutes. Last, we acquired fMRI data for another 10 minutes after the needle was withdrawn. The preprocessing and data analysis were performed using the statistical parametric mapping (SPM8) software. Then the two-sample t-tests were performed between each two groups of different states. We found that during the resting state, brain activities in AD and MCI patients were different from those of control subjects. During the acupuncture and the second resting state after acupuncture, when comparing to resting state, there are several regions showing increased or decreased activities in MCI, AD subjects compared to normal subjects. Most of the regions were involved in the temporal lobe and the frontal lobe, which were closely related to the memory and cognition. In conclusion, we investigated the effect of acupuncture in AD and MCI patients by combing fMRI and traditional acupuncture. Our fMRI study confirmed that acupuncture at Tai chong (Liv3) and He gu (LI4) can activate certain cognitive-related regions in AD and MCI patients.
机译:我们旨在通过功能磁共振成像(fMRI)阐明针灸治疗轻度认知障碍(MCI)和阿尔茨海默氏病(AD)的机制。 36位右撇子受试者(8名MCI患者,14名AD患者和14名健康老年人)参加了这项研究。对所有受试者进行了临床和神经心理学检查。 MRI数据采集是在SIEMENS verio 3-Tesla扫描仪上进行的。功能磁共振成像研究使用单块实验设计。我们首先在最初的3分钟内获取了基线休息状态数据;然后,在接下来的3分钟内,在大冲和合谷穴位进行针刺刺激的过程中,我们获取了功能磁共振成像数据。最后,我们在抽出针头后的10分钟内又获得了fMRI数据。使用统计参数映射(SPM8)软件进行预处理和数据分析。然后,在两组不同状态之间进行两次样本t检验。我们发现,在休息状态下,AD和MCI患者的大脑活动与对照组不同。在针刺和针刺后的第二次静息状态下,与静息状态相比,与正常人相比,MCI,AD受试者中有几个区域活动增加或减少。大部分区域参与颞叶和额叶,这与记忆和认知密切相关。总之,我们通过结合功能磁共振成像和传统针刺研究了针刺对AD和MCI患者的疗效。我们的fMRI研究证实,针刺大冲(Liv3)和合谷(LI4)可以激活AD和MCI患者的某些认知相关区域。

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