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Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

机译：I阶段研究Vorinostat与替替替莫啶蛋白酶组合高档胶质瘤患者：北美脑肿瘤联盟研究04-03

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摘要

PurposeA phase I, dose-finding study of vorinostat in combination with temozolomide (TMZ) was conducted to determine the maximum tolerated dose (MTD), safety, and pharmacokinetics in patients with high-grade glioma (HGG).

机译：目的进行伏立诺他与替莫唑胺（TMZ）结合的I期剂量寻找研究，以确定高级别胶质瘤（HGG）患者的最大耐受剂量（MTD），安全性和药代动力学。

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期刊名称 other
作者
Eudocia Q. Lee; Vinay K. Puduvalli; Joel M. Reid; John G. Kuhn; Kathleen R. Lamborn; Timothy F. Cloughesy; Susan M. Chang; Jan Drappatz; W. K. Alfred Yung; Mark R. Gilbert; H. Ian Robins; Frank S. Lieberman; Andrew B. Lassman; Renee M. McGovern; Jihong Xu; Serena Desideri; Xiabu Ye; Matthew M. Ames; Igor Espinoza-Delgado; Michael D. Prados; Patrick Y. Wen;
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年(卷),期 -1(18),21
年度 -1
页码 6032–6039
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
High-grade glioma Temozolomide Vorinostat HDAC Inhibitor;

机译：高级神经胶质瘤;替莫唑胺;伏立诺他;HDAC抑制剂;

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1. Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: north american brain tumor consortium study 04-03 [J] . LeeE.Q., PuduvalliV.K., ReidJ.M., Clinical cancer research: an official journal of the American Association for Cancer Research . 2012,第21期

机译：伏立诺他联合替莫唑胺在高级神经胶质瘤患者中的I期研究：北美脑肿瘤联合研究04-03
2. A phase II study of O 6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: A Pediatric Brain Tumor Consortium study [J] . WarrenK.E., GururanganS., GeyerJ.R., Journal of neuro-oncology. . 2012,第3期

机译：O 6-苄基鸟嘌呤和替莫唑胺在患有复发性或进行性高级神经胶质瘤和脑干神经胶质瘤的小儿患者的II期研究：小儿脑肿瘤联合会研究
3. Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study. [J] . Prados MD, Yung WK, Wen PY, Cancer chemotherapy and pharmacology. . 2008,第6期

机译：吉非替尼和替莫唑胺在恶性神经胶质瘤患者中的1期试验：一项北美脑肿瘤联合研究。
4. Outcome Prediction for Patient with High-Grade Gliomas from Brain Functional and Structural Networks [C] . Luyan Liu, Han Zhang, Islem Rekik, International conference on medical imaging computing and computer-assisted intervention . 2016

机译：从大脑功能和结构网络对高级别胶质瘤患者的结果预测
5. A phase I study of vincristine, escalating doses of irinotecan, temozolomide and bevacizumab (VIT-B) in pediatric and adolescent patients with recurrent or refractory solid tumors of non-hematopoietic origin [D] . Venkatramani, Rajkumar. 2010

机译：长春新碱，伊非替康，替莫唑胺和贝伐单抗（VIT-B）逐步剂量在患有非造血源性复发或难治性实体瘤的儿童和青少年患者中的I期研究
6. Phase I Study of Temozolomide and Irinotecan for Recurrent Malignant Gliomas in Patients Receiving Enzyme-Inducing Antiepileptic Drugs: A North American BrainTumor Consortium Study [O] . Monica E. Loghin, Michael D. Prados, Patrick Wen, -1

机译：替莫唑胺和伊立替康治疗接受酶诱导抗癫痫药的患者复发性恶性胶质瘤的I期研究：北美BrainTumor联盟研究
7. Phase I Study of Temozolomide and Irinotecan for Recurrent Malignant Gliomas in Patients Receiving Enzyme-Inducing Antiepileptic Drugs: A North American Brain Tumor Consortium Study [O] . Monica E. Loghin, Michael D. Prados, Patrick Wen, 2007

机译：I阶段替代毒性恶性胶质组织诱导酶诱导抗癫痫药物的替代恶性胶质瘤的研究：北美脑肿瘤联盟研究

Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

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