Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver

机译：FGF15 / 19信号转导上调在脂肪肝背景下促进肝细胞癌

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BackgroundUpregulated fibroblast growth factor 19 (FGF19) expression in human hepatocellular carcinoma (HCC) specimens is associated with tumor progression and poor prognosis. Nonalcoholic steatohepatitis (NASH) patients are at high risk for malignant transformation into HCC.

机译：背景人类肝细胞癌（HCC）标本中的成纤维细胞生长因子19（FGF19）表达上调与肿瘤进展和不良预后有关。非酒精性脂肪性肝炎（NASH）患者发生恶性转化为HCC的风险很高。

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期刊名称 Journal of Experimental Clinical Cancer Research : CR
作者
Guozhen Cui; Robert C. Martin; Hang Jin; Xingkai Liu; Harshul Pandit; Hengjun Zhao; Lu Cai; Ping Zhang; Wei Li; Yan Li;
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作者单位

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年(卷),期 2018(37),-1
年度 2018
页码 136
总页数 16
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Fibroblast growth factor 15/19 Steatohepatitis Hepatocellular carcinoma;

机译：成纤维细胞生长因子15/19;脂肪性肝炎;肝细胞癌;

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专利

1. Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration [J] . Alvarez-Sola Gloria, Uriarte Iker, Ujue Latasa M., Gut: Journal of the British Society of Gastroenterology . 2017,第10期

机译：成纤维细胞生长因子15/19（FGF15 / 19）保护饮食诱导的肝脏脂肪变性：开发FGF19的嵌合分子，以促进脂肪肝再生
2. Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma [J] . Ye Yingnan, Guo Jincheng, Xiao Pei, Cancer letters . 2020,第期

机译：巨噬细胞诱导的长度非编码RNA H19上调触发并激活miR-193b / mapk1轴并促进肝细胞癌中的细胞侵袭性
3. Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation [J] . HanZ.-B., ChenH.-Y., FanJ.-W., Journal of Cancer Research and Clinical Oncology . 2012,第1期

机译：microRNA-155的上调促进癌细胞侵袭并预测肝移植后肝细胞癌的不良存活
4. ROLE OF CD36 AND FREE FATTY ACID UPTAKE IN EPITHELIAL-MESENCHYMAL TRANSITION OF HEPATOCELLULAR CARCINOMA CELLS [C] . Christina Chan Biochemical and molecular engineering XX: the next generation of biochemical engineering: from nanoscale to industrial scale . 2017

机译：CD36和游离脂肪酸摄取在肝癌细胞上皮间质转化中的作用
5. Methylome Analysis of Non-alcoholic Fatty Liver Disease-associated Hepatocellular Carcinoma Reveals Etiology-specific Pathway Perturbations [D] . Wu, Qiong. 2019

机译：非酒精脂肪肝病相关肝细胞癌的甲基族分析揭示了病因特异性途径扰动
6. Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma [O] . Yan Li, Weizhong Zhang, Anne Doughtie, 2016

机译：成纤维细胞生长因子19及其受体的上调与从脂肪肝到肝细胞癌的进展有关
7. Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver [O] . Guozhen Cui, Robert C. Martin, Hang Jin, 2018

机译：FGF15 / 19信号传导的上调促进脂肪肝背景中的肝细胞癌

Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver

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