Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

摘要

IntroductionDuring aging, advanced glycation end products (AGEs) accumulate in articular cartilage. In this study we determined whether AGEs induce endoplasmic reticulum (ER) stress and studied the ER stress-activated pathways that stimulate cyclooxygenase-2 (COX-2) expression in human chondrocytes.