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Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anti-cancer Agent Sulforaphane in Rat Lymphocytes

机译：抗癌药物嗜睡酶II期药代动力学和药效学酶基因反应大鼠淋巴细胞的抑制作用

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PURPOSEThis study assesses the pharmacokinetics (PK) and pharmacodynamics (PD) of Nrf2-mediated increased expression of Phase II drug metabolizing enzyme (DME) and antioxidant enzymes which represents an important component of cancer chemoprevention in rat lymphocytes following intravenous (i.v.) administration of an anti-cancer phytochemical sulforaphane (SFN)

机译：目的这项研究评估了Nrf2介导的II期药物代谢酶（DME）和抗氧化酶表达增加的药代动力学（PK）和药效学（PD），这是大鼠静脉内静脉注射静脉注射静脉注射静脉内给药后癌症化学预防的重要组成部分。抗癌植物化学萝卜硫素（SFN）

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期刊名称 other
作者
Hu Wang; Tin Oo Khor; Qian Yang; Ying Huang; Tien-yuan Wu; Constance Lay-Lay Saw; Wen Lin; Ioannis P. Androulakis; Ah-Ng Tony Kong;
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作者单位

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年(卷),期 -1(9),10
年度 -1
页码 2819–2827
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
sulforaphane pharmacokinetics pharmacodynamics lymphocyte phase II genes Nrf2;

机译：萝卜硫烷;药代动力学;药效学;淋巴细胞;II期基因;Nrf2;

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专利

1. Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anticancer Agent Sulforaphane in Rat Lymphocytes. [J] . Hu Wang, Tin Oo Khor, Qian Yang, Molecular pharmaceutics . 2012,第10期

机译：抗癌剂萝卜硫素在大鼠淋巴细胞中的II期药物代谢/抗氧化酶基因应答的药代动力学和药效动力学。
2. Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes [J] . Journal of pharmacokinetics and pharmacodynamics . 2015,第4期

机译：3,3'-二吲哚甲烷（DIM）调节II期药物代谢酶基因表达的药代动力学和药效学
3. Pharmacogenetics of drug metabolizing enzymes and transporters: effects on pharmacokinetics and pharmacodynamics of anticancer agents. [J] . Lee NH Anti-cancer agents in medicinal chemistry . 2010,第8期

机译：药物代谢酶和转运蛋白的药代动力学：对抗癌药的药代动力学和药效学的影响。
4. Effects of L-Arabinose on Drug Metabolizing and Antioxidant Enzymes in Rat [C] . Ziming Yang, Li Zhang, Yueyuan Chen, International Conference on Advanced Design and Manufacturing Engineering . 2016

机译：L-阿拉伯糖对大鼠药物代谢和抗氧化酶的影响
5. Genetic factors that alter the pharmacodynamics of antineoplastic agents independent of alterations in plasma pharmacokinetics [D] . Sissung, Tristan Michael 2009

机译：独立于血浆药代动力学变化而改变抗肿瘤药的药效学的遗传因素
6. Pharmacogenetics of drug metabolizing enzymes and transporters: effects on pharmacokinetics and pharmacodynamics of anticancer agents [O] . Norman H. Lee -1

机译：药物代谢酶和转运蛋白的药物遗传学：对抗癌剂的药代动力学和药效学的影响
7. Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anticancer Agent Sulforaphane in Rat Lymphocytes [O] . Hu Wang, Tin Oo Khor, Qian Yang, 2012

机译：抗癌剂嗜睡在大鼠淋巴细胞中的药代动力学和药效学酶基因反应

Pharmacokinetics and Pharmacodynamics of Phase II Drug Metabolizing/Antioxidant Enzymes Gene Response by Anti-cancer Agent Sulforaphane in Rat Lymphocytes

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