AN FMRI STUDY OF SPATIAL WORKING MEMORY IN CHILDREN WITH PRENATAL ALCOHOL EXPOSURE: CONTRIBUTION OF FAMILIAL HISTORY OF ALCOHOL USE DISORDERS

摘要

BackgroundHeavy prenatal alcohol exposure leads to widespread cognitive deficits, including problems with spatial working memory (SWM). Neuroimaging studies report structural and functional abnormalities in FASD, but interpretations may be complicated by the co-occurrence of a family history of alcoholism. Since, this history is also linked to cognitive deficits and brain abnormalities, it is difficult to determine the extent to which deficits are unique to prenatal alcohol exposure.