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The role of osteocalcin in human glucose metabolism: marker or mediator?

机译:在人体葡萄糖代谢骨钙素的作用:标记物或介质?

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摘要

Increasing evidence supports an association between the skeleton and energy metabolism. These interactions are mediated by a variety of hormones, cytokines and nutrients. Here, the evidence for a role of osteocalcin in the regulation of glucose metabolism in humans is reviewed. Osteocalcin is a bone matrix protein that regulates hydroxyapatite size and shape through its vitamin-K-dependent γ-carboxylated form. In circulation, the concentration of osteocalcin is a measure of bone formation. The undercarboxylated form of osteocalcin is reported to be active in glucose metabolism in mice. Total serum osteocalcin concentrations in humans are inversely associated with measures of glucose metabolism; however, human data are inconclusive with regard to the role of uncarboxylated osteocalcin in glucose metabolism because most studies do not account for the influence of vitamin K on the proportion of undercarboxylated osteocalcin or differentiate between the total and uncarboxylated forms of osteocalcin. Furthermore, most human studies do not concomitantly measure other bone turnover markers to isolate the role of osteocalcin as a measure of bone formation from its effect on glucose metabolism. Carefully designed studies are required to define the role of osteocalcin and its carboxylated or undercarboxylated forms in the regulation of glucose metabolism in humans.
机译:越来越多的证据支持骨骼与能量代谢之间的联系。这些相互作用是由多种激素,细胞因子和营养物质介导的。在此,综述了骨钙素在人类葡萄糖代谢调节中的作用的证据。骨钙素是一种骨基质蛋白,可通过其依赖于维生素K的γ-羧基化形式来调节羟磷灰石的大小和形状。在循环中,骨钙素的浓度是骨形成的量度。据报道骨钙蛋白的羧化不足形式在小鼠的葡萄糖代谢中具有活性。人类血清总骨钙素浓度与葡萄糖代谢指标呈负相关。但是,关于未羧化骨钙素在葡萄糖代谢中的作用,人类数据尚无定论,因为大多数研究并未考虑维生素K对羧化骨钙素不足的比例的影响,也不区分骨钙素的总形式和未羧化形式。此外,大多数人类研究并没有同时测量其他骨转换标志物以从骨钙素对葡萄糖代谢的影响中分离出骨钙素作为骨形成指标的作用。需要仔细设计的研究来确定骨钙蛋白及其羧化或羧化形式在人类葡萄糖代谢调节中的作用。

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