Recruitment of Black Subjects for a Natural History Study of Intracerebral Hemorrhage

摘要

Historically, recruitment of minority subjects for clinical research has been challenging. We developed culturally-tailored recruitment materials for a longitudinal, natural history study of intracerebral hemorrhage (ICH) and trained recruiting coordinators in cultural competence. Of 285 subjects meeting inclusion criteria, 158 (55% of eligible) agreed to participate (60% of eligible blacks vs. 45% of eligible non-blacks, p = 0.02). Of those enrolled, 138 (87%) agreed to participate in the genetic sub-study (86% of blacks vs. 90% of non-blacks enrolled, p = 0.78). Of those subjects who refused enrollment, lack of interest in research (42%) was the most common reason for the study as a whole. A higher rate of enrollment was achieved in blacks vs. non-blacks in this ICH clinical research study employing culturally-tailored recruitment approaches and training of recruitment coordinators to overcome traditional recruitment barriers to research participation in minority patients.