A Prospective Randomized Trial of Peri-Operative Seizure Prophylaxis in Patients with Intraparenchymal Brain Tumors

摘要

ObjectSeizures are a potentially devastating complication of surgical resection of brain tumors. Consequently, many neurosurgeons administer prophylactic anti-epileptic drugs (AEDs) in the peri-operative period. However, it is currently unclear whether peri-operative AEDs should be routinely administered to patients with brain tumors who have never had a seizure. Consequently, we conducted a prospective, randomized trial examining the use of phenytoin for post-operative seizure prophylaxis in patients with supratentorial brain metastases or gliomas undergoing surgical resection.