Catalytic Enantioselective Epoxidation of Tertiary Allylic- and Homoallylic Alcohols

摘要

An efficient and versatile method for the enantioselective epoxidation of both tertiary allylic- and homoallylic alcohols catalyzed by Hf(IV)-bishydroxamic acid (BHA) complexes is described. Asymmetric epoxidation, kinetic resolution, and desymmetrization have been developed demonstrating the flexible nature of the system, Hf(IV)-BHA. This is the first report in which these substrates were obtained with enantioselectivities up to 99%.