The CCND1 870GA polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

摘要

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genomewide association studies of multiple myeloma totaling 1,661 patients we investigated risk for developing a specific tumor karyotype. The t(11;14) (q13;q32) translocation in which CCDN1 is placed under the control of the immunoglobin heavy chain enhancer was strongly associated with the CCDN1 870G>A polymorphism (P =7.96 x10^-11). These results provide for a model in which a constitutional genetic factor is associated with risk of a specific chromosomal translocation.