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Randomised Phase II Trial (NCT00637975) Evaluating Activity and Toxicity of Two Different Escalating Strategies for Pregabalin and Oxycodone Combination Therapy for Neuropathic Pain in Cancer Patients

机译：II期随机试验（NCT00637975）评估癌症患者中普瑞巴林和羟考酮联合治疗神经性疼痛的两种不同递增策略的活性和毒性

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PurposeNeuropathic pain is commonly associated with cancer. Current treatments include combination opioid and adjuvant therapies, but no guidelines are available for dose escalation strategies. This phase II study compared the efficacy and tolerability of two dose escalation strategies for oxycodone and pregabalin combination therapy.

机译：目的神经性疼痛通常与癌症有关。目前的治疗方法包括阿片类药物和辅助治疗的联合治疗，但尚无指导性指南可用于剂量递增策略。这项II期研究比较了羟考酮和普瑞巴林联合治疗的两种剂量递增策略的疗效和耐受性。

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Marina Chiara Garassino; Sheila Piva; Nicla La Verde; Ilaria Spagnoletti; Vittorio Iorno; Claudia Carbone; Antonio Febbraro; Anna Bianchi; Annalisa Bramati; Anna Moretti; Monica Ganzinelli; Mirko Marabese; Marta Gentili; Valter Torri; Gabriella Farina;
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年(卷),期 -1(8),4
年度 -1
页码 e59981
总页数 6
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1. Pregabalin and Amitriptyline as Monotherapy or as Low-Dose Combination in Patients of Neuropathic Pain: A Randomized, Controlled Trial to Evaluate Efficacy and Safety in an Eastern India Teaching Hospital [J] . Sourav Chakrabarty, Samar Biswas, Tamoghna Maiti, Annals of Indian Academy of Neurology . 2019,第4期

机译：普瑞巴林和阿米替林作为单药治疗或神经病患者的低剂量组合：随机，受控试验，以评估在印度东部教学医院的疗效和安全性
2. Protocol for a phase III pragmatic stepped wedge cluster randomised controlled trial comparing the effectiveness and cost-effectiveness of screening and guidelines with, versus without, implementation strategies for improving pain in adults with cancer attending outpatient oncology and palliative care services: the Stop Cancer PAIN trial [J] . Tim Luckett, Jane Phillips, Meera Agar, BMC Health Services Research . 2018,第1期

机译：III阶段的议定书务实的阶梯式楔形集群随机化对照试验比较筛查和准则的有效性和成本效益，而不是实施癌症，以便在出席门诊肿瘤和姑息治疗服务中提高成人疼痛：停止癌症疼痛试验
3. Treatment sequence with either irinotecan/cetuximab followed by FOLFOX-4 or the reverse strategy in metastatic colorectal cancer patients progressing after first-line FOLFIRI/bevacizumab: An Italian Group for the Study of Gastrointestinal Cancer phase III, randomised trial comparing two sequences of therapy in colorectal metastatic patients [J] . European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2017,第期

机译：用伊立替康/西替昔单抗的治疗序列，然后进行Folfox-4或转移性结肠直肠癌患者的反向策略，在第一线Folfiri / Bevacizumab后进展：用于研究胃肠癌期III的意大利组，随机试验比较两种治疗序列结肠直肠转移性患者
4. Evaluation of Acute Pain Response to Intravenous Morphine in Japanese Patients with Cancer Pain Prior to Choice of Therapy [C] . K. Murakawa, K. Moriyama, H. Noma, International Pain Clinic . 2004

机译：评价治疗前癌症疼痛患者静脉内吗啡的急性疼痛反应
5. Sexuality and gynaecological cancer: A randomised control trial to evaluate the effectiveness of a group psychoeducational intervention in improving the sexual health of women with gynaecological cancer treated with radiotherapy [D] . Jeffries, Sherryl Anne 2003

机译：性与妇科癌症：一项随机对照试验，旨在评估团体心理教育干预措施对经放射治疗的妇科癌症妇女改善性健康的有效性
6. Long-term evaluation of combined prolonged-release oxycodone and naloxone in patients with moderate-to-severe chronic pain: pooled analysis of extension phases of two Phase III trials [O] . M Blagden, J Hafer, H Duerr, -1

机译：对中度至重度慢性疼痛患者的缓释羟考酮和纳洛酮联合长期治疗的评估：两项三期试验延长期的合并分析
7. Randomised phase II trial (NCT00637975) evaluating activity and toxicity of two different escalating strategies for pregabalin and oxycodone combination therapy for neuropathic pain in cancer patients. [O] . Marina Chiara Garassino, Sheila Piva, Nicla La Verde, 2013

机译：随机II期试验（NCT00637975）评估两种不同升级策略对普瑞巴林和羟考酮联合治疗癌症患者神经性疼痛的活性和毒性。

Randomised Phase II Trial (NCT00637975) Evaluating Activity and Toxicity of Two Different Escalating Strategies for Pregabalin and Oxycodone Combination Therapy for Neuropathic Pain in Cancer Patients

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