Enantioselective Thiourea-Catalyzed Intramolecular Cope-Type Hydroamination

摘要

Catalysis of Cope-type rearrangements of bishomoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products, and represents a complementary approach to metal-catalyzed methods.